What's new in dry eye research today? | Oct 19, 2026

【Title】Emerging microfluidic diagnostic systems for anterior segment diseases: a systematic review

【Journal】Graefes Arch Clin Exp Ophthalmol

【Authors】Zahra Heidari; Amin Amiri Delouei; Ali Tarokh

【Summary】This systematic review evaluated microfluidic diagnostic systems for anterior segment diseases, including corneal ectatic disorders, dry eye, infectious keratitis, and glaucoma. Of 228 publications identified, 11 studies met the inclusion criteria. Cornea-on-a-chip models enabled dynamic assessment of corneal wound healing, barrier function, and biomechanics. Paper-based and wearable microfluidic platforms supported objective, low-volume tear analysis, with electrochemical sensing strongly correlating with conventional methods (R² ≥ 0.99). Integrated microfluidic RT-PCR systems enabled rapid multiplex pathogen detection, while implantable and wearable sensors facilitated continuous intraocular pressure monitoring. Despite promising diagnostic performance, clinical translation remains limited by factors including calibration requirements and the small evidence base.

【Title】Long-Term Corneal Nerve and Ocular Surface Findings After COVID-19 Requiring Hospitalisation: An Observational Follow-Up Study

【Journal】Clin Ophthalmol

【Authors】Andreas Guttmann; Nora Woltsche; Astrid Heidinger; et al.

【Summary】This observational follow-up study evaluated 26 previously hospitalized COVID-19 patients at a median of 2.77 years after infection, comparing 16 patients with persistent ocular symptoms and 10 without symptoms. The symptomatic group had significantly higher OSDI scores (41.5 ± 17.7 vs 21.8 ± 11.3; p = 0.005), but objective tear film, ocular surface, and corneal nerve parameters did not differ significantly between groups. Dendritic cells and microneuromas were common in both groups. Older age was associated with lower corneal nerve fibre density and length among symptomatic patients, and topical oxybuprocaine failed to relieve symptoms in 43.8% of symptomatic participants. The findings suggest possible neuropathic or neuroinflammatory involvement, although the small sample limits interpretation.